| DATE | OPPONENT | TIME (GMT+8) | COMPETITION | LOCATION |
|---|
| Sunday, August 07 | (H)Brighton | 9:00 PM | Premier League | Old Trafford |
| Sunday, August 14 | (A)Brentford | 12:30 AM | Premier League | Brentford Community Stadium |
| Tuesday, August 23 | (H)Liverpool | 3:00 AM | Premier League | Old Trafford |
| Saturday, August 27 | (A)Southampton | 7:30 PM | Premier League | St. Mary’s Stadium |
| Friday, September 02 | (A)Leicester | 3:00 AM | Premier League | King Power Stadium |
| Sunday, September 04 | (H)Arsenal | 11:30 PM | Premier League | Old Trafford |
| Sunday, September 11 | (A)Crystal Palace | 11:30 PM | Premier League | Selhurst Park |
| Sunday, September 18 | (H)Leeds | 9:00 PM | Premier League | Old Trafford |
| Saturday, October 01 | (A)Man City | 10:00 PM | Premier League | Etihad Stadium |
| Saturday, October 08 | (A)Everton | 10:00 PM | Premier League | Goodison Park |
| Saturday, October 15 | (H)Newcastle | 10:00 PM | Premier League | Old Trafford |
| Thursday, October 20 | (H)Tottenham | 3:00 AM | Premier League | Old Trafford |
| Saturday, October 22 | (A)Chelsea | 10:00 PM | Premier League | Stamford Bridge |
| Saturday, October 29 | (H)West Ham | 10:00 PM | Premier League | Old Trafford |
| Saturday, November 05 | (A)Aston Villa | 11:00 PM | Premier League | Villa Park |
| Saturday, November 12 | (A)Fulham | 11:00 PM | Premier League | Craven Cottage |
| Monday, December 26 | (H)Nottm Forest | 11:00 PM | Premier League | Old Trafford |
| Saturday, December 31 | (A)Wolves | 11:00 PM | Premier League | Molineux Stadium |
| Monday, January 02 | (H)Bournemouth | 11:00 PM | Premier League | Old Trafford |
| Saturday, January 14 | (H)Man City | 11:00 PM | Premier League | Old Trafford |
| Saturday, January 21 | (A)Arsenal | 11:00 PM | Premier League | Emirates Stadium |
| Saturday, February 04 | (H)Crystal Palace | 11:00 PM | Premier League | Old Trafford |
| Saturday, February 11 | (A)Leeds | 11:00 PM | Premier League | Elland Road |
| Saturday, February 18 | (H)Leicester | 11:00 PM | Premier League | Old Trafford |
| Saturday, February 25 | (H)Brentford | 11:00 PM | Premier League | Old Trafford |
| Saturday, March 04 | (A)Liverpool | 11:00 PM | Premier League | Anfield |
| Saturday, March 11 | (H)Southampton | 11:00 PM | Premier League | Old Trafford |
| Saturday, March 18 | (A)Brighton | 11:00 PM | Premier League | The American Express Community Stadium |
| Saturday, April 01 | (A)Newcastle | 10:00 PM | Premier League | St. James’ Park |
| Saturday, April 08 | (H)Everton | 10:00 PM | Premier League | Old Trafford |
| Saturday, April 15 | (A)Nottm Forest | 10:00 PM | Premier League | The City Ground |
| Saturday, April 22 | (H)Chelsea | 10:00 PM | Premier League | Old Trafford |
| Wednesday, April 26 | (A)Tottenham | 2:45 AM | Premier League | Tottenham Hotspur Stadium |
| Saturday, April 29 | (H)Aston Villa | 10:00 PM | Premier League | Old Trafford |
| Saturday, May 06 | (A)West Ham | 10:00 PM | Premier League | London Stadium |
| Saturday, May 13 | (H)Wolves | 10:00 PM | Premier League | Old Trafford |
| Saturday, May 20 | (A)Bournemouth | 10:00 PM | Premier League | Vitality Stadium |
| Sunday, May 28 | (H)Fulham | 11:00 PM | Premier League | Old Trafford |